WP2: Organic- and chemoenzymatic synthesis of natural products and derivatives

WP2 is responsible for preparing all synthetic molecules for DigiBiotics. The synthetic molecules will be peptides or peptide like due to the known membrane interaction potentials of antimicrobial peptides and cyclic in order to restrict and control the conformational freedom of these middle-space molecules. The peptides will be prepared by solid-phase synthesis (SPP) or by solution phase techniques. Our laboratory is equipped both for parallel synthesis and automatic solid phase synthesis, and has in addition state of the art purification equipment. WP2 has also capacity to prepare non-genetically encoded amino acid derivatives labelled with isotopes or chromophores and side-chains with unusual properties.