Hanna-Kirsti, Annette and Susann were invited to contribute to a conference and workshop on AMR at IIT Roorkee last week. It was a fascinating visit and we were very well taken care of by our collaborators in the iCarba project, Ranjana Pathania and Naveen Navani.
We are looking forward to the extra hands on our carbapenemase projects.
Very welcome to Master student Harald Magnussen and “soon Postdoc” Marc Boomgaren.
… with the title: From Waste to Value: Carbon Dioxide as a Resource
He will spend two years with Prof. Huw Davies at Emory University to develop carbene chemistry and then return to us for a third year.
Janakiram got 2 papers focusing on sulfonyl ylides (one research article and one review) accepted this month. Very well done!
Vaitla J, Bayer A, Hopmann KH. Ang. Chem. Int. Ed. 2018, accepted. Iron‐Catalyzed Carbenoid Transfer Reactions of Vinyl Sulfoxonium Ylides: An Experimental and Computational Study. doi: 10.1002/anie.201810451.
Vaitla J, Bayer A. Synthesis 2018, accepted. Sulfoxonium ylide derived metal carbenoids in organic synthesis.
Of course to look at there CO2 treatment!
The present study describes the synthesis and biological studies of a small series of head‐to‐tail cyclic tetrapeptides of the general structure c(Lys‐β2,2‐Xaa‐Lys) containing one lipophilic β2,2‐amino acid and Lys, Gly, Ala, or Phe as the Xaa residue in the sequence. The peptides were investigated for antimicrobial activity against gram‐positive and gram‐negative reference strains and 30 multiresistant clinical isolates including strains with extended spectrum β‐lactamase—carbapenemase (ESBL‐CARBA) production. Toxicity was determined against human red blood cells. The most potent peptides showed high activity against the gram‐positive clinical isolates with minimum inhibitory concentrations of 4–8 μg/mL and low haemolytic activity. The combination of high antimicrobial activity and low toxicity shows that these cyclic tetrapeptides containing lipophilic β2,2‐amino acids form a valuable scaffold for designing novel antimicrobial agents.
Aya is presenting her poster to the Head of Department. Well-done!
Thank you for a great jobb. And the best wishes for the future.