Natural product chemistry

The society relies on a continuous development of new drugs, either to replace older and less efficient drugs, or even more important, to address clinical needs that are unmet today. “Natural products play an important role in the development of drugs and it is estimated that approximately 80% of prescribed drugs today are either natural products or have been derived from natural products. Our work focuses on the development of efficient synthetic strategies of bioactive natural product and systematic modification of the original structure to gain an understanding of the structural features that are important for the desired biological activity.

Related publications: 
♦ Synlett 2018, 1303. Aldol condensations on a 3-alkylidene-2,5-diketopiperazine –  synthesis of two marine natural products. doi: 10.1055/s-0036-1591755
♦ Org. Biomol. Chem. 2016, 7570. Efficient and scalable synthesis of α,α-disubstituted β–amino amides. Open access! doi10.1039/C6OB01219A
♦ Org. Lett. 2015, 122. A Concise Total Synthesis of Breitfussin A and B. Open access! doi: 10.1021/ol503348n