{"id":449,"date":"2020-08-23T22:04:21","date_gmt":"2020-08-23T20:04:21","guid":{"rendered":"https:\/\/site.uit.no\/bayerlab\/?page_id=449"},"modified":"2026-04-16T21:30:31","modified_gmt":"2026-04-16T19:30:31","slug":"antibiotic-resistance-breakers","status":"publish","type":"page","link":"https:\/\/site.uit.no\/bayerlab\/research\/antibiotic-resistance-breakers\/","title":{"rendered":"Antibiotic resistance breakers"},"content":{"rendered":"\n

In their latest report the WHO warns \u201cA post-antibiotic era \u2014 in which common infections and minor injuries can kill \u2014 far from being an apocalyptic fantasy, is instead a very real possibility for the 21st century<\/em>\u201d. Carbapenem antibiotics, e.g. meropenem, are usually the last line of defence against otherwise drug-resistant bacterial infections. However, the continuous evolution of bacteria possessing carbapenem-destroying enzymes \u2013 carbapenemases \u2013 threatens the utility of meropenem and related antibiotics. We aim to develop antibiotic resistance breakers that prevent the carbapenemases from destroying the last-line antibiotics and thereby revitalize the antibiotics for clinical use. Our group has identified several compound classes with potential to be developed to carbapenemase inhibitors. As part of the LacZyme<\/a> group we have develop inhibitors through structure-based drug design and fragment-based approaches.<\/p>\n\n\n\n

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Related publications:<\/strong>
\u2666 J. Med. Chem. <\/span>2025<\/b>, 13421. Design and SAR Analysis of Phenylboronic Acid-Based Inhibitors for Sensitizing KPC-2-Producing Klebsiella pneumoniae to \u03b2-Lactam Antibiotics<\/i>. doi: <\/span>10.1021\/acs.jmedchem.5c00058<\/a><\/span><\/em><\/p>\n\n\n\n

\u2666<\/em> Eu. J. Med. Chem. 2024<\/strong>, 116140. Fluorinated Captopril Analogues Inhibit Metallo-\u00df-Lactamases and Facilitate Structure Determination of NDM-1 Binding Pose. doi: 10.1016\/j.ejmech.2024.116140<\/a><\/em>\"\"<\/p>\n\n\n\n

\u2666 Bioorg. Med. Chem. 2020<\/strong>, 115598. Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-\u03b2-lactamases. doi: 10.1016\/j.bmc.2020.115598<\/a>.<\/em><\/p>\n\n\n\n

\u2666 Eur. J. Med.Chem. 2018<\/strong>, 634. A focused fragment library targeting the antibiotic resistance enzyme \u2013 Oxacillinase-48: synthesis, structural evaluation and inhibitor design. <\/em>UiT\u00b4s open research archive; <\/a><\/p>\n\n\n\n

\u2666 Eur. J. Med.Chem. 2017<\/strong>, 159. Metallo-\u03b2-lactamase inhibitors by bioisosteric replacement: preparation, activity and binding. <\/em>UiT\u00b4s open research archive<\/a>;<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

In their latest report the WHO warns \u201cA post-antibiotic era \u2014 in which common infections and minor injuries can kill \u2014 far from being an apocalyptic fantasy, is instead a very real possibility for the 21st century\u201d. Carbapenem antibiotics, e.g. … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":826,"featured_media":221,"parent":12,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-449","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"\nAntibiotic resistance breakers - BAYER LAB<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/site.uit.no\/bayerlab\/research\/antibiotic-resistance-breakers\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Antibiotic resistance breakers - BAYER LAB\" \/>\n<meta property=\"og:description\" content=\"In their latest report the WHO warns \u201cA post-antibiotic era \u2014 in which common infections and minor injuries can kill \u2014 far from being an apocalyptic fantasy, is instead a very real possibility for the 21st century\u201d. Carbapenem antibiotics, e.g. … Continue reading →\" \/>\n<meta property=\"og:url\" content=\"https:\/\/site.uit.no\/bayerlab\/research\/antibiotic-resistance-breakers\/\" \/>\n<meta property=\"og:site_name\" content=\"BAYER LAB\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-16T19:30:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/site.uit.no\/bayerlab\/wp-content\/uploads\/sites\/278\/2018\/01\/GraphicalAbstract.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2280\" \/>\n\t<meta property=\"og:image:height\" content=\"722\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/site.uit.no\\\/bayerlab\\\/research\\\/antibiotic-resistance-breakers\\\/\",\"url\":\"https:\\\/\\\/site.uit.no\\\/bayerlab\\\/research\\\/antibiotic-resistance-breakers\\\/\",\"name\":\"Antibiotic resistance breakers - BAYER LAB\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/site.uit.no\\\/bayerlab\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/site.uit.no\\\/bayerlab\\\/research\\\/antibiotic-resistance-breakers\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/site.uit.no\\\/bayerlab\\\/research\\\/antibiotic-resistance-breakers\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/site.uit.no\\\/bayerlab\\\/wp-content\\\/uploads\\\/sites\\\/278\\\/2018\\\/01\\\/GraphicalAbstract.jpg\",\"datePublished\":\"2020-08-23T20:04:21+00:00\",\"dateModified\":\"2026-04-16T19:30:31+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/site.uit.no\\\/bayerlab\\\/research\\\/antibiotic-resistance-breakers\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/site.uit.no\\\/bayerlab\\\/research\\\/antibiotic-resistance-breakers\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/site.uit.no\\\/bayerlab\\\/research\\\/antibiotic-resistance-breakers\\\/#primaryimage\",\"url\":\"https:\\\/\\\/site.uit.no\\\/bayerlab\\\/wp-content\\\/uploads\\\/sites\\\/278\\\/2018\\\/01\\\/GraphicalAbstract.jpg\",\"contentUrl\":\"https:\\\/\\\/site.uit.no\\\/bayerlab\\\/wp-content\\\/uploads\\\/sites\\\/278\\\/2018\\\/01\\\/GraphicalAbstract.jpg\",\"width\":2280,\"height\":722},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/site.uit.no\\\/bayerlab\\\/research\\\/antibiotic-resistance-breakers\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/site.uit.no\\\/bayerlab\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research\",\"item\":\"https:\\\/\\\/site.uit.no\\\/bayerlab\\\/research\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Antibiotic resistance breakers\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/site.uit.no\\\/bayerlab\\\/#website\",\"url\":\"https:\\\/\\\/site.uit.no\\\/bayerlab\\\/\",\"name\":\"BAYER LAB\",\"description\":\"at UiT\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/site.uit.no\\\/bayerlab\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Antibiotic resistance breakers - BAYER LAB","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/site.uit.no\/bayerlab\/research\/antibiotic-resistance-breakers\/","og_locale":"en_US","og_type":"article","og_title":"Antibiotic resistance breakers - BAYER LAB","og_description":"In their latest report the WHO warns \u201cA post-antibiotic era \u2014 in which common infections and minor injuries can kill \u2014 far from being an apocalyptic fantasy, is instead a very real possibility for the 21st century\u201d. 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