{"id":449,"date":"2020-08-23T22:04:21","date_gmt":"2020-08-23T20:04:21","guid":{"rendered":"https:\/\/site.uit.no\/bayerlab\/?page_id=449"},"modified":"2026-04-16T21:30:31","modified_gmt":"2026-04-16T19:30:31","slug":"antibiotic-resistance-breakers","status":"publish","type":"page","link":"https:\/\/site.uit.no\/bayerlab\/research\/antibiotic-resistance-breakers\/","title":{"rendered":"Antibiotic resistance breakers"},"content":{"rendered":"\n<p>In their latest report the WHO warns \u201cA post-antibiotic era \u2014<em> in which common infections and minor injuries can kill \u2014 far from being an apocalyptic fantasy, is instead a very real possibility for the 21st century<\/em>\u201d. Carbapenem antibiotics, e.g. meropenem, are usually the last line of defence against otherwise drug-resistant bacterial infections. However, the continuous evolution of bacteria possessing carbapenem-destroying enzymes \u2013 carbapenemases \u2013 threatens the utility of meropenem and related antibiotics. We aim to develop antibiotic resistance breakers that prevent the carbapenemases from destroying the last-line antibiotics and thereby revitalize the antibiotics for clinical use. Our group has identified several compound classes with potential to be developed to carbapenemase inhibitors. As part of the <a href=\"https:\/\/uit.no\/prosjekter\/prosjekt?p_document_id=467132\">LacZyme<\/a> group we have develop inhibitors through structure-based drug design and fragment-based approaches.<\/p>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-8cf370e7 wp-block-group-is-layout-flex\">\n<p><strong>Related publications:<\/strong><br><em>\u2666 <span lang=\"EN-US\">J. Med. Chem.<span class=\"apple-converted-space\"> <\/span><b>2025<\/b>, 13421. <i>Design and SAR Analysis of Phenylboronic Acid-Based Inhibitors for Sensitizing KPC-2-Producing Klebsiella pneumoniae to \u03b2-Lactam Antibiotics<\/i>. <span class=\"apple-converted-space\">doi: <\/span><a title=\"DOI URL\" href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.5c00058\">10.1021\/acs.jmedchem.5c00058<\/a><\/span><\/em><\/p>\n\n\n\n<p><em>\u2666<\/em>  Eu. J. Med. Chem. <strong>2024<\/strong>, 116140. <em>Fluorinated Captopril Analogues Inhibit Metallo-\u00df-Lactamases and Facilitate Structure Determination of NDM-1 Binding Pose. doi: <a href=\"https:\/\/doi.org\/10.1016\/j.ejmech.2024.116140\">10.1016\/j.ejmech.2024.116140<\/a><\/em><img fetchpriority=\"high\" decoding=\"async\" width=\"584\" height=\"125\" src=\"https:\/\/site.uit.no\/bayerlab\/wp-content\/uploads\/sites\/278\/2024\/01\/GraphicalAbstract-1024x220.png\" alt=\"\"><\/p>\n\n\n\n<p><em>\u2666 Bioorg. Med. Chem. <strong>2020<\/strong>, 115598. Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-\u03b2-lactamases. doi: <a title=\"Persistent link using digital object identifier\" href=\"https:\/\/doi.org\/10.1016\/j.bmc.2020.115598\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"doi\">10.1016\/j.bmc.2020.115598<\/a>.<\/em><\/p>\n\n\n\n<p><em>\u2666&nbsp;Eur. J. Med.Chem. <strong>2018<\/strong>, 634. A focused fragment library targeting the antibiotic resistance enzyme \u2013 Oxacillinase-48: synthesis, structural evaluation and inhibitor design. <\/em><a href=\"http:\/\/hdl.handle.net\/10037\/12942\">UiT\u00b4s open research archive;&nbsp;<\/a><\/p>\n\n\n\n<p>\u2666 Eur. J. Med.Chem. <strong>2017<\/strong>, 159. <em>Metallo-\u03b2-lactamase inhibitors by bioisosteric replacement: preparation, activity and binding. <\/em><a href=\"http:\/\/hdl.handle.net\/10037\/12626\">UiT\u00b4s open research archive<\/a>;<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>In their latest report the WHO warns \u201cA post-antibiotic era \u2014 in which common infections and minor injuries can kill \u2014 far from being an apocalyptic fantasy, is instead a very real possibility for the 21st century\u201d. Carbapenem antibiotics, e.g. &hellip; <a href=\"https:\/\/site.uit.no\/bayerlab\/research\/antibiotic-resistance-breakers\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":826,"featured_media":221,"parent":12,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-449","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/site.uit.no\/bayerlab\/wp-json\/wp\/v2\/pages\/449","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/site.uit.no\/bayerlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/site.uit.no\/bayerlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/site.uit.no\/bayerlab\/wp-json\/wp\/v2\/users\/826"}],"replies":[{"embeddable":true,"href":"https:\/\/site.uit.no\/bayerlab\/wp-json\/wp\/v2\/comments?post=449"}],"version-history":[{"count":3,"href":"https:\/\/site.uit.no\/bayerlab\/wp-json\/wp\/v2\/pages\/449\/revisions"}],"predecessor-version":[{"id":758,"href":"https:\/\/site.uit.no\/bayerlab\/wp-json\/wp\/v2\/pages\/449\/revisions\/758"}],"up":[{"embeddable":true,"href":"https:\/\/site.uit.no\/bayerlab\/wp-json\/wp\/v2\/pages\/12"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/site.uit.no\/bayerlab\/wp-json\/wp\/v2\/media\/221"}],"wp:attachment":[{"href":"https:\/\/site.uit.no\/bayerlab\/wp-json\/wp\/v2\/media?parent=449"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}