{"id":294,"date":"2018-08-26T08:27:04","date_gmt":"2018-08-26T06:27:04","guid":{"rendered":"https:\/\/site.uit.no\/bayerlab\/?p=294"},"modified":"2018-08-26T08:27:04","modified_gmt":"2018-08-26T06:27:04","slug":"a-new-paper-from-mariannes-phd-is-out-congratulations","status":"publish","type":"post","link":"https:\/\/site.uit.no\/bayerlab\/2018\/08\/26\/a-new-paper-from-mariannes-phd-is-out-congratulations\/","title":{"rendered":"A new paper from Mariannes PhD is out! Congratulations."},"content":{"rendered":"<div class=\"abstract-group\">\n<section id=\"section-1-en\" class=\"article-section article-section__abstract\" lang=\"en\">\n<h3 class=\"article-section__header main abstractlang_en main\">Abstract<\/h3>\n<div class=\"article-section__content en main\">\n<p>The present study describes the synthesis and biological studies of a small series of head\u2010to\u2010tail cyclic tetrapeptides of the general structure c(Lys\u2010\u03b2<sup>2,2<\/sup>\u2010Xaa\u2010Lys) containing one lipophilic \u03b2<sup>2,2<\/sup>\u2010amino acid and Lys, Gly, Ala, or Phe as the Xaa residue in the sequence. The peptides were investigated for antimicrobial activity against gram\u2010positive and gram\u2010negative reference strains and 30 multiresistant clinical isolates including strains with extended spectrum \u03b2\u2010lactamase\u2014carbapenemase (ESBL\u2010CARBA) production. Toxicity was determined against human red blood cells. The most potent peptides showed high activity against the gram\u2010positive clinical isolates with minimum inhibitory concentrations of 4\u20138\u00a0\u03bcg\/mL and low haemolytic activity. The combination of high antimicrobial activity and low toxicity shows that these cyclic tetrapeptides containing lipophilic \u03b2<sup>2,2<\/sup>\u2010amino acids form a valuable scaffold for designing novel antimicrobial agents.<\/p>\n<\/div>\n<\/section>\n<\/div>\n<p>https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/psc.3117<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract The present study describes the synthesis and biological studies of a small series of head\u2010to\u2010tail cyclic tetrapeptides of the general structure c(Lys\u2010\u03b22,2\u2010Xaa\u2010Lys) containing one lipophilic \u03b22,2\u2010amino acid and Lys, Gly, Ala, or Phe as the Xaa residue in the &hellip; <a href=\"https:\/\/site.uit.no\/bayerlab\/2018\/08\/26\/a-new-paper-from-mariannes-phd-is-out-congratulations\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":826,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-294","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>A new paper from Mariannes PhD is out! 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