Research Article: Buchwald–Hartwig in lipid solvents

As a follow-up from the paper “Lipids as versatile solvents for chemical synthesis, Ashot , Kathrin and Annette are now presenting their work on the Buchwald–Hartwig Amination reaction using said solvents. Congratulations to all authors!

Abstract:
The development of green Buchwald–Hartwig aminations has long been considered challenging, due to the high sensitivity of the reaction to the environment. Here we show that food-grade and waste vegetable oils, triglycerides originating from animals, and natural waxes can serve as excellent green solvents for Buchwald–Hartwig amination. We further demonstrate that amphiphiles and trace ingredients present in triglycerides as additives have a decisive effect on the yields of Buchwald–Hartwig aminations.

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For a list of publications by members of the CHOCO group, see our Publications page 🙂