We recently attended the ISQBP President’s meeting, which is held every two years acting as a meeting point for the community working on molecular simulations of biomolecular systems. This years meeting was held in Barcelona, Spain ?? and the conference program was packed with both impressive topics and names (see programme). Johan Åqvist from the CUBE3 gave a talk the first day on entropy and enzyme catalysis and we participated with a poster covering enzyme temperature adaptation.