Successful development of bacteriocins into therapeutic formulation for treatment of MRSA-skin infection in a murine model

The emergence of antibiotic resistant pathogens has caused a serious world-wide problem in infection treatments in recent years. One of these pathogens is the methicillin-resistant Staphylococcus aureus (MRSA) which is a major cause of skin and soft tissue infections. Alternative strategies and novel sources of antimicrobials to solve antibiotic resistance …

Designing ecologically optimized pneumococcal vaccines using population genomic

Streptococcus pneumoniae (the pneumococcus) is a common nasopharyngeal commensal that can cause invasive pneumococcal disease (IPD). Each component of current protein–polysaccharide conjugate vaccines (PCVs) generally induces immunity specific to one of the approximately 100 pneumococcal serotypes, and typically eliminates it from carriage and IPD through herd immunity. Overall carriage rates …