New article from the Skrydstrup Group: Main element chemistry enables gas-cylinder-free hydroformylations

Congratulations to Samuel K. Pedersen, Haraldur G. Gudmundsson, Dennis U. Nielsen, Bjarke S. Donslund, Hans Christian D. Hammershøj, Kim Daasbjerg and Troels Skrydstrup!


Industrially, aldehydes are produced annually on a multimillion-tonne scale via the hydroformylation of olefins with syngas (CO/H2 mixture). Nonetheless, this transformation has not found frequent use in the laboratory. Here we report on a simple strategy for the concerted generation of syngas from two accessible and crystalline main element compounds with just water as the primary activator for syngas release. By decoupling the syngas formation and consumption via a two-chamber reactor ww demonstrate this low-pressure, low-temperature and near-stoichiometric hydroformylation operates efficiently on a diverse array of terminal olefins without the need for expensive equipment. Our approach provides unique opportunities to access aldehydes in a safe and reliable manner with further adaptation to the synthesis of a range of pharmaceuticals and relevant molecules thereof. This strategy is adaptable to carbon isotope labelling as demonstrated by the use of a 13CO releasing molecule. We anticipate this hydroformylation approach will provide a complementary toolbox for drug discovery and development.38/s419

The article was published in Nature Catalysis


Date for the Annual and Industry meeting in NordCO2

We are happy to announce the dates for the Annual and Industry meeting for NordCO2 for 2020! The digital meeting will take place 21-23.10.20 from 2-4PM and 28-29.10.20 from 2-4PM. Please keep the dates and time available. A detailed program will be sent to all participants. Welcome!

E-meetings in the fall of 2020

Due to the situation with Covid-19 it has been decided to have an industry and annual E-meeting in the fall of 2020. More information and the date will be announced! The annual meeting planned in Reykjavik for 2020 has been postponed to 2021.

Steering Committee Meeting in NordCO2

A digital Steering Committee meeting in NordCO2 was held 17th of August 2020. Present were Kathrin H. Hopmann (UiT), Ainara Nova (UiO), Vidar Remi Jensen (UiB), Jere Mannisto (HU), Egill Skúlason (UoI), Troels Skrydstrup (AU), Sascha Ott (UU), Mårten Ahlquist (KTH), Odile Eisenstein (ICGM), Trine Andreassen (UIT – adm. coordinator).


New article published by Mårten Ahlquist’s group

Congratulations to Juan Angel De Gracia Triviño and Mårten S. G. Ahquist!

Oxide Relay: An Efficient Mechanism for Catalytic Water Oxidation at Hydrophobic Electrode Surfaces


In order to combine the advantages of molecular catalysts with the stability of solid-state catalysts, hybrid systems with catalysts immobilized on carbon nanotubes are prominent candidates. Here we explore our recent mechanistic proposal for Ru(tda)(py)2, the oxide relay mechanism, in a hybrid system from an experimental study. It reacts with the same efficiency but with increased stability compared to the homogeneous molecular catalyst. We used the empirical valence bond method and molecular dynamics with enhanced sampling approaches to investigate the two key steps in the mechanism: the intramolecular O–O bond formation and the OH nucleophilic attack. The results on these calculations show that the oxide relay mechanism remains unaltered in the new environment. We believe that the principles should apply to other oxide containing dangling groups and to other metal centers, opening new possibilities of future developments on hybrid molecular catalyst-based water splitting devices.

The article was published in The Journal of Physical Chemistry Letters.