{"id":1241,"date":"2020-01-21T17:04:22","date_gmt":"2020-01-21T16:04:22","guid":{"rendered":"https:\/\/site.uit.no\/nordco2\/?p=1241"},"modified":"2024-10-11T12:25:58","modified_gmt":"2024-10-11T10:25:58","slug":"new-research-article-from-the-nova-group","status":"publish","type":"post","link":"https:\/\/site.uit.no\/nordco2\/2020\/01\/21\/new-research-article-from-the-nova-group\/","title":{"rendered":"New Research article from the Nova group"},"content":{"rendered":"<p><strong>Abstract<\/strong><br \/>\nThe catalytic hydrogenation of amides is an atom economical method to synthesize amines. Previously, it was serendipitously discovered that the combination of a secondary amide co-catalyst with (<small><sup>iPr<\/sup><\/small>PNP)Fe(H)(CO) (<small><sup>iPr<\/sup><\/small>PNP = N[CH<small><sub>2<\/sub><\/small>CH<small><sub>2<\/sub><\/small>(P<small><sup>i<\/sup><\/small>Pr<small><sub>2<\/sub><\/small>)]<small><sub>2<\/sub><\/small><small><sup>\u2212<\/sup><\/small>), results in a highly active base metal system for deaminative amide hydrogenation. Here, we use DFT to develop an improved co-catalyst for amide hydrogenation. Initially, we computationally evaluated the ability of a series of co-catalysts to accelerate the turnover-limiting proton transfer during C\u2013N bond cleavage and poison the (<small><sup>iPr<\/sup><\/small>PNP)Fe(H)(CO) catalyst through a side reaction. TBD (triazabicyclodecene) was identified as the leading co-catalyst. It was experimentally confirmed that when TBD is combined with (<small><sup>iPr<\/sup><\/small>PNP)Fe(H)(CO) a remarkably active system for amide hydrogenation is generated. TBD also enhances the activity of other catalysts for amide hydrogenation and our results provide guidelines for the rational design of future co-catalysts.<img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-1242 aligncenter\" src=\"https:\/\/site.uit.no\/nordco2\/wp-content\/uploads\/sites\/344\/2020\/04\/ezgif.com-gif-maker-1.jpg\" alt=\"\" width=\"270\" height=\"189\" \/><\/p>\n<p style=\"text-align: center\"><strong>Read at:<\/strong><a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2020\/SC\/C9SC03812D#!divAbstract\"><img decoding=\"async\" class=\"size-full wp-image-1243 aligncenter\" src=\"https:\/\/site.uit.no\/nordco2\/wp-content\/uploads\/sites\/344\/2020\/04\/rsc-logo.png\" alt=\"\" width=\"639\" height=\"178\" srcset=\"https:\/\/site.uit.no\/nordco2\/wp-content\/uploads\/sites\/344\/2020\/04\/rsc-logo.png 639w, https:\/\/site.uit.no\/nordco2\/wp-content\/uploads\/sites\/344\/2020\/04\/rsc-logo-300x84.png 300w\" sizes=\"(max-width: 639px) 100vw, 639px\" \/><\/a><\/p>\n<p>For a list of publications by the members of NordCO<sub>2<\/sub>, see our <a href=\"https:\/\/site.uit.no\/nordco2\/publications\/\">Publications<\/a> page!<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract The catalytic hydrogenation of amides is an atom economical method to synthesize amines. Previously, it was serendipitously discovered that the combination of a secondary &hellip;<\/p>\n","protected":false},"author":514,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-1241","post","type-post","status-publish","format-standard","hentry","category-research"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New Research article from the Nova group - Nordic Consortium for CO2 Conversion<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/site.uit.no\/nordco2\/2020\/01\/21\/new-research-article-from-the-nova-group\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New Research article from the Nova group - Nordic Consortium for CO2 Conversion\" \/>\n<meta property=\"og:description\" content=\"Abstract The catalytic hydrogenation of amides is an atom economical method to synthesize amines. Previously, it was serendipitously discovered that the combination of a secondary &hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/site.uit.no\/nordco2\/2020\/01\/21\/new-research-article-from-the-nova-group\/\" \/>\n<meta property=\"og:site_name\" content=\"Nordic Consortium for CO2 Conversion\" \/>\n<meta property=\"article:published_time\" content=\"2020-01-21T16:04:22+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-10-11T10:25:58+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/site.uit.no\/nordco2\/wp-content\/uploads\/sites\/344\/2020\/04\/ezgif.com-gif-maker-1.jpg\" \/>\n<meta name=\"author\" content=\"joehh\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"joehh\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/2020\\\/01\\\/21\\\/new-research-article-from-the-nova-group\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/2020\\\/01\\\/21\\\/new-research-article-from-the-nova-group\\\/\"},\"author\":{\"name\":\"joehh\",\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/#\\\/schema\\\/person\\\/993cf3b27a956c23c8da21d29fe6bd7c\"},\"headline\":\"New Research article from the Nova group\",\"datePublished\":\"2020-01-21T16:04:22+00:00\",\"dateModified\":\"2024-10-11T10:25:58+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/2020\\\/01\\\/21\\\/new-research-article-from-the-nova-group\\\/\"},\"wordCount\":178,\"publisher\":{\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/2020\\\/01\\\/21\\\/new-research-article-from-the-nova-group\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/wp-content\\\/uploads\\\/sites\\\/344\\\/2020\\\/04\\\/ezgif.com-gif-maker-1.jpg\",\"articleSection\":[\"Research\"],\"inLanguage\":\"en-GB\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/2020\\\/01\\\/21\\\/new-research-article-from-the-nova-group\\\/\",\"url\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/2020\\\/01\\\/21\\\/new-research-article-from-the-nova-group\\\/\",\"name\":\"New Research article from the Nova group - 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