{"id":2523,"date":"2022-02-15T09:43:46","date_gmt":"2022-02-15T08:43:46","guid":{"rendered":"https:\/\/site.uit.no\/nordco2\/?p=2523"},"modified":"2024-10-11T12:20:38","modified_gmt":"2024-10-11T10:20:38","slug":"research-article-uit-and-hu","status":"publish","type":"post","link":"https:\/\/site.uit.no\/nordco2\/2022\/02\/15\/research-article-uit-and-hu\/","title":{"rendered":"Research Article: UiT and HU"},"content":{"rendered":"\n<p>The first NordCO<small><sub>2<\/sub><\/small> collaboration paper of the year is from UiT and HU, involving PhD students Aleksi (HU), Dat (UiT), and Jere (HU) from Kathrin&#8217;s and Timo&#8217;s groups. Together, they studied the the synthesis of butyrolactones from CO<small><sub>2<\/sub><\/small>&nbsp;using&nbsp;&nbsp;titanacyclopropane as mediator.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/pubs.rsc.org\/en\/Image\/Get?imageInfo.ImageType=GA&amp;imageInfo.ImageIdentifier.ManuscriptID=D2CC00446A&amp;imageInfo.ImageIdentifier.Year=2022\" alt=\"Graphical abstract: Titanium isopropoxide-mediated cis-selective synthesis of 3,4-substituted butyrolactones from CO2\" \/><\/figure>\n<\/div>\n\n\n<p><strong>Title:<\/strong><br><a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2022\/cc\/d2cc00446a\" data-type=\"URL\" data-id=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2022\/cc\/d2cc00446a\">Titanium isopropoxide-mediated\u00a0<em>cis<\/em>-selective synthesis of 3,4-substituted butyrolactones from CO<sub>2<\/sub><\/a><\/p>\n\n\n\n<p><strong>Abstract:<\/strong><br>We report a Ti(OiPr)<small><sub>4<\/sub><\/small>-mediated multicomponent reaction, which produces 3,4-substituted\u00a0<em>cis<\/em>-\u03b4-lactones from alkyl magnesium chloride, benzaldehyde and CO<small><sub>2<\/sub><\/small>. The key intermediate, titanacyclopropane, is formed\u00a0<em>in situ<\/em>\u00a0from Ti(OiPr)<small><sub>4<\/sub><\/small>\u00a0and a Grignard reagent, which enables 1,2-dinucleophilic reactivity that is used to insert carbon dioxide and an aldehyde. An alternative reaction route is also described where a primary alkene is used to create the titanacyclopropane. A computational analysis of the elementary steps shows that the carbon dioxide and the aldehyde insertion proceeds through an inner-sphere mechanism. A variety of\u00a0<em>cis<\/em>-butyrolactones can be synthesized with up to 7\u2006:\u20061 diastereoselectivity and 77% yield.<\/p>\n\n\n\n<p>Find a list of publications by&nbsp;NordCO<sub>2<\/sub>&nbsp;members on our&nbsp;<a href=\"https:\/\/site.uit.no\/nordco2\/publications\/\">Publications<\/a>&nbsp;page&nbsp;\ud83d\ude42<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The first NordCO2 collaboration paper of the year is from UiT and HU, involving PhD students Aleksi (HU), Dat (UiT), and Jere (HU) from Kathrin&#8217;s &hellip;<\/p>\n","protected":false},"author":514,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"image","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2523","post","type-post","status-publish","format-image","hentry","category-research","post_format-post-format-image"],"_links":{"self":[{"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/posts\/2523","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/users\/514"}],"replies":[{"embeddable":true,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/comments?post=2523"}],"version-history":[{"count":3,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/posts\/2523\/revisions"}],"predecessor-version":[{"id":2918,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/posts\/2523\/revisions\/2918"}],"wp:attachment":[{"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/media?parent=2523"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/categories?post=2523"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/tags?post=2523"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}