{"id":2920,"date":"2022-04-08T10:11:00","date_gmt":"2022-04-08T08:11:00","guid":{"rendered":"https:\/\/site.uit.no\/nordco2\/?p=2920"},"modified":"2024-10-11T12:20:38","modified_gmt":"2024-10-11T10:20:38","slug":"research-article-au","status":"publish","type":"post","link":"https:\/\/site.uit.no\/nordco2\/2022\/04\/08\/research-article-au\/","title":{"rendered":"Research Article: AU"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"219\" src=\"https:\/\/site.uit.no\/nordco2\/wp-content\/uploads\/sites\/344\/2024\/01\/chem202200997-toc-0001-m-1024x219.jpg\" alt=\"graphical abstract\" class=\"wp-image-2921\" srcset=\"https:\/\/site.uit.no\/nordco2\/wp-content\/uploads\/sites\/344\/2024\/01\/chem202200997-toc-0001-m-1024x219.jpg 1024w, https:\/\/site.uit.no\/nordco2\/wp-content\/uploads\/sites\/344\/2024\/01\/chem202200997-toc-0001-m-300x64.jpg 300w, https:\/\/site.uit.no\/nordco2\/wp-content\/uploads\/sites\/344\/2024\/01\/chem202200997-toc-0001-m-768x164.jpg 768w, https:\/\/site.uit.no\/nordco2\/wp-content\/uploads\/sites\/344\/2024\/01\/chem202200997-toc-0001-m-1280x274.jpg 1280w, https:\/\/site.uit.no\/nordco2\/wp-content\/uploads\/sites\/344\/2024\/01\/chem202200997-toc-0001-m.jpg 1359w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><strong>Title:<\/strong><br><a href=\"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full\/10.1002\/chem.202200997\" data-type=\"URL\" data-id=\"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full\/10.1002\/chem.202200997\">Pd-Catalyzed Difluoromethylations of Aryl Boronic Acids, Halides, and Pseudohalides with ICF<sub>2<\/sub>H Generated ex Situ<\/a><\/p>\n\n\n\n<p><strong>Abstract:<\/strong><br>An expedient ex-situ generation of difluoroiodomethane (DFIM) and its immediate use in a Pd-catalyzed difluoromethylation of aryl boronic acids and ester derivatives in a two-chamber reactor is reported. Heating a solution of bromodifluoroacetic acid with sodium iodide in sulfolane proved to be effective for the generation of near stoichiometric amounts of DFIM for the ensuing catalytic coupling step. A two-step difluoromethylation of aryl (pseudo)halides with tetrahydroxydiboron as a low-cost reducing agent, both promoted by Pd catalysis, proved effective to install this fluorine-containing C<sub>1<\/sub>\u00a0group onto several pharmaceutically relevant molecules. Finally, the method proved adaptable to deuterium incorporation by simply adding D<sub>2<\/sub>O to the DFIM-generating chamber.<\/p>\n\n\n\n<p>Find a list of publications by&nbsp;NordCO<sub>2<\/sub>&nbsp;members on our&nbsp;<a href=\"https:\/\/site.uit.no\/nordco2\/publications\/\">Publications<\/a>&nbsp;page&nbsp;\ud83d\ude42<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Title:Pd-Catalyzed Difluoromethylations of Aryl Boronic Acids, Halides, and Pseudohalides with ICF2H Generated ex Situ Abstract:An expedient ex-situ generation of difluoroiodomethane (DFIM) and its immediate use &hellip;<\/p>\n","protected":false},"author":514,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"image","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2920","post","type-post","status-publish","format-image","hentry","category-research","post_format-post-format-image"],"_links":{"self":[{"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/posts\/2920","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/users\/514"}],"replies":[{"embeddable":true,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/comments?post=2920"}],"version-history":[{"count":1,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/posts\/2920\/revisions"}],"predecessor-version":[{"id":2922,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/posts\/2920\/revisions\/2922"}],"wp:attachment":[{"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/media?parent=2920"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/categories?post=2920"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/tags?post=2920"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}