{"id":2934,"date":"2022-11-15T10:27:00","date_gmt":"2022-11-15T09:27:00","guid":{"rendered":"https:\/\/site.uit.no\/nordco2\/?p=2934"},"modified":"2024-10-11T12:20:38","modified_gmt":"2024-10-11T10:20:38","slug":"research-article-au-2","status":"publish","type":"post","link":"https:\/\/site.uit.no\/nordco2\/2022\/11\/15\/research-article-au-2\/","title":{"rendered":"Research Article: AU"},"content":{"rendered":"\n<p><strong>Title:<\/strong><br><a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2022\/sc\/d2sc04220g\" data-type=\"URL\" data-id=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2022\/sc\/d2sc04220g\">Direct formation and site-selective elaboration of methionine sulfoximine in polypeptides<\/a><\/p>\n\n\n\n<p><strong>Abstract:<\/strong><br>Sulfoximines are emerging moieties for medicinal and biological chemistry, due in part to their efficacy in selective inhibition of amide-forming enzymes such as \u03b3-glutamylcysteine synthetase. While small-molecule sulfoximines such as methionine sulfoximine (MSO) and its derivatives are well studied, structures with methionine sulfoximine residues within complex polypeptides have been generally inaccessible. This paper describes a straightforward means of late-stage one-step oxidation of methionine residues within polypeptides to afford NH-sulfoximines. We also present chemoselective subsequent elaboration, most notably by copper(<small>II<\/small>)-mediated N\u2013H cross-coupling at methionine sulfoximine residues with arylboronic acid reagents. This development serves as a strategy to incorporate diverse sulfoximine structures within natural polypeptides, and also identifies the methionine sulfoximine residue as a new site for bioorthogonal, chemoselective bioconjugation.<\/p>\n\n\n\n<p>Find a list of publications by\u00a0NordCO<sub>2<\/sub>\u00a0members on our\u00a0<a href=\"https:\/\/site.uit.no\/nordco2\/publications\/\">Publications<\/a>\u00a0page\u00a0\ud83d\ude42<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Title:Direct formation and site-selective elaboration of methionine sulfoximine in polypeptides Abstract:Sulfoximines are emerging moieties for medicinal and biological chemistry, due in part to their efficacy &hellip;<\/p>\n","protected":false},"author":514,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"image","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2934","post","type-post","status-publish","format-image","hentry","category-research","post_format-post-format-image"],"_links":{"self":[{"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/posts\/2934","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/users\/514"}],"replies":[{"embeddable":true,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/comments?post=2934"}],"version-history":[{"count":1,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/posts\/2934\/revisions"}],"predecessor-version":[{"id":2936,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/posts\/2934\/revisions\/2936"}],"wp:attachment":[{"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/media?parent=2934"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/categories?post=2934"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/tags?post=2934"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}