{"id":2934,"date":"2022-11-15T10:27:00","date_gmt":"2022-11-15T09:27:00","guid":{"rendered":"https:\/\/site.uit.no\/nordco2\/?p=2934"},"modified":"2024-10-11T12:20:38","modified_gmt":"2024-10-11T10:20:38","slug":"research-article-au-2","status":"publish","type":"post","link":"https:\/\/site.uit.no\/nordco2\/2022\/11\/15\/research-article-au-2\/","title":{"rendered":"Research Article: AU"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Title:<\/strong><br><a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2022\/sc\/d2sc04220g\" data-type=\"URL\" data-id=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2022\/sc\/d2sc04220g\">Direct formation and site-selective elaboration of methionine sulfoximine in polypeptides<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Abstract:<\/strong><br>Sulfoximines are emerging moieties for medicinal and biological chemistry, due in part to their efficacy in selective inhibition of amide-forming enzymes such as \u03b3-glutamylcysteine synthetase. While small-molecule sulfoximines such as methionine sulfoximine (MSO) and its derivatives are well studied, structures with methionine sulfoximine residues within complex polypeptides have been generally inaccessible. This paper describes a straightforward means of late-stage one-step oxidation of methionine residues within polypeptides to afford NH-sulfoximines. We also present chemoselective subsequent elaboration, most notably by copper(<small>II<\/small>)-mediated N\u2013H cross-coupling at methionine sulfoximine residues with arylboronic acid reagents. This development serves as a strategy to incorporate diverse sulfoximine structures within natural polypeptides, and also identifies the methionine sulfoximine residue as a new site for bioorthogonal, chemoselective bioconjugation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Find a list of publications by\u00a0NordCO<sub>2<\/sub>\u00a0members on our\u00a0<a href=\"https:\/\/site.uit.no\/nordco2\/publications\/\">Publications<\/a>\u00a0page\u00a0\ud83d\ude42<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Title:Direct formation and site-selective elaboration of methionine sulfoximine in polypeptides Abstract:Sulfoximines are emerging moieties for medicinal and biological chemistry, due in part to their efficacy &hellip;<\/p>\n","protected":false},"author":514,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"image","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2934","post","type-post","status-publish","format-image","hentry","category-research","post_format-post-format-image"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - 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