{"id":2953,"date":"2023-02-07T11:06:00","date_gmt":"2023-02-07T10:06:00","guid":{"rendered":"https:\/\/site.uit.no\/nordco2\/?p=2953"},"modified":"2024-10-11T12:20:38","modified_gmt":"2024-10-11T10:20:38","slug":"research-article-au-4","status":"publish","type":"post","link":"https:\/\/site.uit.no\/nordco2\/2023\/02\/07\/research-article-au-4\/","title":{"rendered":"Research Article: AU"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/media.springernature.com\/lw685\/springer-static\/image\/art%3A10.1038%2Fs44160-022-00223-0\/MediaObjects\/44160_2022_223_Figa_HTML.png?as=webp\" alt=\"graphical abstract\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Title:<\/strong><br><a href=\"https:\/\/www.nature.com\/articles\/s44160-022-00223-0\" data-type=\"URL\" data-id=\"https:\/\/www.nature.com\/articles\/s44160-022-00223-0\">Multi-carbon labelling of active pharmaceutical ingredients enabled by a three-gas surrogate hydroformylation<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Abstract:<\/strong><br>Drug metabolism and pharmacokinetic studies play a crucial role in drug discovery and development programmes, assessing a lead drug candidate\u2019s efficacy and safety profile. Quantitative bioanalytical assessment of analytes with mass spectrometry requires the use of stable carbon-13-labelled compounds with a molecular mass difference of \u22653\u2009daltons. The incorporation of three or more carbon isotopes into drug candidates is not trivial, often requiring lengthy and costly syntheses. Here we report a dual catalytic strategy for the synthesis of multi-carbon-labelled isotopologues of active pharmaceutical ingredients. This approach uses isotopically labelled gas surrogates in a three-chamber reactor for sequential release of alkenes, carbon monoxide and hydrogen followed by low-pressure hydroformylation to generate multi-labelled alkyl aldehydes. The method\u2019s utility has been demonstrated through the synthesis of multiple labelled\u00a0<em>N<\/em>-alkyl bioactive compounds, site-selective carbon-13 and deuterium introduction and for triple-carbon labelling of small molecules combined with \u03b1-functionalization.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Find a list of publications by\u00a0NordCO<sub>2<\/sub>\u00a0members on our\u00a0<a href=\"https:\/\/site.uit.no\/nordco2\/publications\/\">Publications<\/a>\u00a0page\u00a0\ud83d\ude42<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Title:Multi-carbon labelling of active pharmaceutical ingredients enabled by a three-gas surrogate hydroformylation Abstract:Drug metabolism and pharmacokinetic studies play a crucial role in drug discovery and &hellip;<\/p>\n","protected":false},"author":514,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"image","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2953","post","type-post","status-publish","format-image","hentry","category-research","post_format-post-format-image"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - 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