{"id":2960,"date":"2023-02-14T11:13:00","date_gmt":"2023-02-14T10:13:00","guid":{"rendered":"https:\/\/site.uit.no\/nordco2\/?p=2960"},"modified":"2024-10-11T12:20:38","modified_gmt":"2024-10-11T10:20:38","slug":"research-article-au-5","status":"publish","type":"post","link":"https:\/\/site.uit.no\/nordco2\/2023\/02\/14\/research-article-au-5\/","title":{"rendered":"Research Article: AU"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/pubs.acs.org\/cms\/10.1021\/jacsau.2c00708\/asset\/images\/large\/au2c00708_0008.jpeg\" alt=\"graphical abstract\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Title:<\/strong><br><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacsau.2c00708\" data-type=\"URL\" data-id=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacsau.2c00708\">Rapid Access to Carbon-Isotope-Labeled Alkyl and Aryl Carboxylates Applying Palladacarboxylates<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Abstract:<br>Herein, we report a strategy for the formation of isotopically labeled carboxylic esters from boronic esters\/acids using a readily accessible palladium carboxylate complex as an organometallic source of isotopically labeled functional groups. The reaction allows access to either unlabeled or full\u00a0<sup>13<\/sup>C- or\u00a0<sup>14<\/sup>C-isotopically labeled carboxylic esters, and the method is characterized by its operational simplicity, mild conditions, and general substrate scope. Our protocol is further extended to a carbon isotope replacement strategy, involving an initial decarbonylative borylation procedure. Such an approach allows access to isotopically labeled compounds directly from the unlabeled pharmaceutical, which can have implications for drug discovery programs.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Find a list of publications by\u00a0NordCO<sub>2<\/sub>\u00a0members on our\u00a0<a href=\"https:\/\/site.uit.no\/nordco2\/publications\/\">Publications<\/a>\u00a0page\u00a0\ud83d\ude42<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Title:Rapid Access to Carbon-Isotope-Labeled Alkyl and Aryl Carboxylates Applying Palladacarboxylates Abstract:Herein, we report a strategy for the formation of isotopically labeled carboxylic esters from boronic &hellip;<\/p>\n","protected":false},"author":514,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"image","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2960","post","type-post","status-publish","format-image","hentry","category-research","post_format-post-format-image"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - 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