{"id":2984,"date":"2023-09-20T13:23:00","date_gmt":"2023-09-20T11:23:00","guid":{"rendered":"https:\/\/site.uit.no\/nordco2\/?p=2984"},"modified":"2024-10-11T12:19:45","modified_gmt":"2024-10-11T10:19:45","slug":"research-article-au-6","status":"publish","type":"post","link":"https:\/\/site.uit.no\/nordco2\/2023\/09\/20\/research-article-au-6\/","title":{"rendered":"Research Article: AU"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/cms\/asset\/f1db3594-9731-4a5e-932e-95f2ec88e72f\/ejoc202300843-toc-0001-m.jpg\" alt=\"graphical abstract\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Title:<\/strong><br><a href=\"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/ejoc.202300843\" data-type=\"URL\" data-id=\"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/ejoc.202300843\"><em>Ex-Situ<\/em>\u00a0Generation of Bis(trifluoromethyl)disulfide and Applications to Trifluoromethylthiolation Reactions<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Abstract:<\/strong><br>Herein, a convenient and operationally simple protocol for the\u00a0<em>ex-situ<\/em>\u00a0generation of bis(trifluoromethyl)disulfide from the readily available and commercial Langlois reagent is reported. The one-step synthesis of the toxic and volatile CF<sub>3<\/sub>SSCF<sub>3<\/sub>\u00a0is performed in a two-chamber reactor with simple PPh<sub>3<\/sub>\u00a0and\u00a0<em>N<\/em>-bromosuccinimide as the activator, allowing for the safe handling and tandem utilization in direct trifluoromethylthiolation reactions. The versatility of the\u00a0<em>ex-situ<\/em>\u00a0generated CF<sub>3<\/sub>SSCF<sub>3<\/sub>\u00a0is demonstrated in known electrophilic, nucleophilic, and a radical trifluoromethylthiolation reactions. Furthermore, the application of the CF<sub>3<\/sub>SSCF<sub>3<\/sub>\u00a0in a copper-catalyzed cross-coupling with boronic acids is disclosed, showing good to excellent yields of trifluoromethyl-substituted aryl products, including pharmaceutically relevant molecules.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Find a list of publications by\u00a0NordCO<sub>2<\/sub>\u00a0members on our\u00a0<a href=\"https:\/\/site.uit.no\/nordco2\/publications\/\">Publications<\/a>\u00a0page\u00a0\ud83d\ude42<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Title:Ex-Situ\u00a0Generation of Bis(trifluoromethyl)disulfide and Applications to Trifluoromethylthiolation Reactions Abstract:Herein, a convenient and operationally simple protocol for the\u00a0ex-situ\u00a0generation of bis(trifluoromethyl)disulfide from the readily available and commercial &hellip;<\/p>\n","protected":false},"author":514,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"image","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2984","post","type-post","status-publish","format-image","hentry","category-research","post_format-post-format-image"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - 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