{"id":3449,"date":"2024-05-17T10:36:00","date_gmt":"2024-05-17T08:36:00","guid":{"rendered":"https:\/\/site.uit.no\/nordco2\/?p=3449"},"modified":"2024-10-11T12:19:44","modified_gmt":"2024-10-11T10:19:44","slug":"research-article-au-9","status":"publish","type":"post","link":"https:\/\/site.uit.no\/nordco2\/2024\/05\/17\/research-article-au-9\/","title":{"rendered":"Research Article: AU"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/onlinelibrary.wiley.com\/cms\/asset\/06e1cc61-c789-4002-90dc-0d4d0e16d7e3\/anie202405344-toc-0001-m.jpg\" alt=\"Graphical Abstract\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Title:<\/strong><br><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202405344\" data-type=\"link\" data-id=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202405344\">Selective Macrocyclization of Unprotected Peptides with an Ex Situ Gaseous Linchpin Reagent<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Abstract:<\/strong><br>Peptide cyclization has dramatic effects on a variety of important properties, enhancing metabolic stability, limiting conformational flexibility, and altering cellular entry and intracellular localization. The hydrophilic, polyfunctional nature of peptides creates chemoselectivity challenges in macrocyclization, especially for natural sequences without biorthogonal handles. Herein, we describe a gaseous sulfonyl chloride derived reagent that achieves amine\u2013amine, amine\u2013phenol, and amine\u2013aniline crosslinking through a minimalist linchpin strategy that affords macrocyclic urea or carbamate products. The cyclization reaction is metal-mediated and involves a novel application of sulfine species that remains unexplored in aqueous or biological contexts. The aqueous method delivers unique cyclic or bicyclic topologies directly from a variety of natural bioactive peptides without the need for protecting-group strategies.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Find a list of publications by\u00a0NordCO<sub>2<\/sub>\u00a0members on our\u00a0<a href=\"https:\/\/site.uit.no\/nordco2\/publications\/\">Publications<\/a>\u00a0page\u00a0\ud83d\ude42<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Title:Selective Macrocyclization of Unprotected Peptides with an Ex Situ Gaseous Linchpin Reagent Abstract:Peptide cyclization has dramatic effects on a variety of important properties, enhancing metabolic &hellip;<\/p>\n","protected":false},"author":514,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"image","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-3449","post","type-post","status-publish","format-image","hentry","category-research","post_format-post-format-image"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Research Article: AU - Nordic Consortium for CO2 Conversion<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/site.uit.no\/nordco2\/2024\/05\/17\/research-article-au-9\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research Article: AU - Nordic Consortium for CO2 Conversion\" \/>\n<meta property=\"og:description\" content=\"Title:Selective Macrocyclization of Unprotected Peptides with an Ex Situ Gaseous Linchpin Reagent Abstract:Peptide cyclization has dramatic effects on a variety of important properties, enhancing metabolic &hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/site.uit.no\/nordco2\/2024\/05\/17\/research-article-au-9\/\" \/>\n<meta property=\"og:site_name\" content=\"Nordic Consortium for CO2 Conversion\" \/>\n<meta property=\"article:published_time\" content=\"2024-05-17T08:36:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-10-11T10:19:44+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/onlinelibrary.wiley.com\/cms\/asset\/06e1cc61-c789-4002-90dc-0d4d0e16d7e3\/anie202405344-toc-0001-m.jpg\" \/>\n<meta name=\"author\" content=\"joehh\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"joehh\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/2024\\\/05\\\/17\\\/research-article-au-9\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/2024\\\/05\\\/17\\\/research-article-au-9\\\/\"},\"author\":{\"name\":\"joehh\",\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/#\\\/schema\\\/person\\\/993cf3b27a956c23c8da21d29fe6bd7c\"},\"headline\":\"Research Article: AU\",\"datePublished\":\"2024-05-17T08:36:00+00:00\",\"dateModified\":\"2024-10-11T10:19:44+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/2024\\\/05\\\/17\\\/research-article-au-9\\\/\"},\"wordCount\":146,\"publisher\":{\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/2024\\\/05\\\/17\\\/research-article-au-9\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/onlinelibrary.wiley.com\\\/cms\\\/asset\\\/06e1cc61-c789-4002-90dc-0d4d0e16d7e3\\\/anie202405344-toc-0001-m.jpg\",\"articleSection\":[\"Research\"],\"inLanguage\":\"en-GB\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/2024\\\/05\\\/17\\\/research-article-au-9\\\/\",\"url\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/2024\\\/05\\\/17\\\/research-article-au-9\\\/\",\"name\":\"Research Article: AU - Nordic Consortium for CO2 Conversion\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/2024\\\/05\\\/17\\\/research-article-au-9\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/2024\\\/05\\\/17\\\/research-article-au-9\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/onlinelibrary.wiley.com\\\/cms\\\/asset\\\/06e1cc61-c789-4002-90dc-0d4d0e16d7e3\\\/anie202405344-toc-0001-m.jpg\",\"datePublished\":\"2024-05-17T08:36:00+00:00\",\"dateModified\":\"2024-10-11T10:19:44+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/2024\\\/05\\\/17\\\/research-article-au-9\\\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/2024\\\/05\\\/17\\\/research-article-au-9\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/2024\\\/05\\\/17\\\/research-article-au-9\\\/#primaryimage\",\"url\":\"https:\\\/\\\/onlinelibrary.wiley.com\\\/cms\\\/asset\\\/06e1cc61-c789-4002-90dc-0d4d0e16d7e3\\\/anie202405344-toc-0001-m.jpg\",\"contentUrl\":\"https:\\\/\\\/onlinelibrary.wiley.com\\\/cms\\\/asset\\\/06e1cc61-c789-4002-90dc-0d4d0e16d7e3\\\/anie202405344-toc-0001-m.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/2024\\\/05\\\/17\\\/research-article-au-9\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Article: AU\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/#website\",\"url\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/\",\"name\":\"Nordic Consortium for CO2 Conversion\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/#organization\",\"name\":\"Nordic Consortium for CO2 Conversion\",\"url\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/wp-content\\\/uploads\\\/sites\\\/344\\\/2018\\\/01\\\/cropped-logonewnordco2_2-2.png\",\"contentUrl\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/wp-content\\\/uploads\\\/sites\\\/344\\\/2018\\\/01\\\/cropped-logonewnordco2_2-2.png\",\"width\":174,\"height\":96,\"caption\":\"Nordic Consortium for CO2 Conversion\"},\"image\":{\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/#\\\/schema\\\/person\\\/993cf3b27a956c23c8da21d29fe6bd7c\",\"name\":\"joehh\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/41b39828da26f7150fc97cb70bc12710fe106a864e4f01c116292a086677dd77?s=96&d=blank&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/41b39828da26f7150fc97cb70bc12710fe106a864e4f01c116292a086677dd77?s=96&d=blank&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/41b39828da26f7150fc97cb70bc12710fe106a864e4f01c116292a086677dd77?s=96&d=blank&r=g\",\"caption\":\"joehh\"},\"url\":\"https:\\\/\\\/site.uit.no\\\/nordco2\\\/author\\\/joehh\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Research Article: AU - Nordic Consortium for CO2 Conversion","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/site.uit.no\/nordco2\/2024\/05\/17\/research-article-au-9\/","og_locale":"en_GB","og_type":"article","og_title":"Research Article: AU - Nordic Consortium for CO2 Conversion","og_description":"Title:Selective Macrocyclization of Unprotected Peptides with an Ex Situ Gaseous Linchpin Reagent Abstract:Peptide cyclization has dramatic effects on a variety of important properties, enhancing metabolic &hellip;","og_url":"https:\/\/site.uit.no\/nordco2\/2024\/05\/17\/research-article-au-9\/","og_site_name":"Nordic Consortium for CO2 Conversion","article_published_time":"2024-05-17T08:36:00+00:00","article_modified_time":"2024-10-11T10:19:44+00:00","og_image":[{"url":"https:\/\/onlinelibrary.wiley.com\/cms\/asset\/06e1cc61-c789-4002-90dc-0d4d0e16d7e3\/anie202405344-toc-0001-m.jpg","type":"","width":"","height":""}],"author":"joehh","twitter_card":"summary_large_image","twitter_misc":{"Written by":"joehh","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/site.uit.no\/nordco2\/2024\/05\/17\/research-article-au-9\/#article","isPartOf":{"@id":"https:\/\/site.uit.no\/nordco2\/2024\/05\/17\/research-article-au-9\/"},"author":{"name":"joehh","@id":"https:\/\/site.uit.no\/nordco2\/#\/schema\/person\/993cf3b27a956c23c8da21d29fe6bd7c"},"headline":"Research Article: AU","datePublished":"2024-05-17T08:36:00+00:00","dateModified":"2024-10-11T10:19:44+00:00","mainEntityOfPage":{"@id":"https:\/\/site.uit.no\/nordco2\/2024\/05\/17\/research-article-au-9\/"},"wordCount":146,"publisher":{"@id":"https:\/\/site.uit.no\/nordco2\/#organization"},"image":{"@id":"https:\/\/site.uit.no\/nordco2\/2024\/05\/17\/research-article-au-9\/#primaryimage"},"thumbnailUrl":"https:\/\/onlinelibrary.wiley.com\/cms\/asset\/06e1cc61-c789-4002-90dc-0d4d0e16d7e3\/anie202405344-toc-0001-m.jpg","articleSection":["Research"],"inLanguage":"en-GB"},{"@type":"WebPage","@id":"https:\/\/site.uit.no\/nordco2\/2024\/05\/17\/research-article-au-9\/","url":"https:\/\/site.uit.no\/nordco2\/2024\/05\/17\/research-article-au-9\/","name":"Research Article: AU - Nordic Consortium for CO2 Conversion","isPartOf":{"@id":"https:\/\/site.uit.no\/nordco2\/#website"},"primaryImageOfPage":{"@id":"https:\/\/site.uit.no\/nordco2\/2024\/05\/17\/research-article-au-9\/#primaryimage"},"image":{"@id":"https:\/\/site.uit.no\/nordco2\/2024\/05\/17\/research-article-au-9\/#primaryimage"},"thumbnailUrl":"https:\/\/onlinelibrary.wiley.com\/cms\/asset\/06e1cc61-c789-4002-90dc-0d4d0e16d7e3\/anie202405344-toc-0001-m.jpg","datePublished":"2024-05-17T08:36:00+00:00","dateModified":"2024-10-11T10:19:44+00:00","breadcrumb":{"@id":"https:\/\/site.uit.no\/nordco2\/2024\/05\/17\/research-article-au-9\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/site.uit.no\/nordco2\/2024\/05\/17\/research-article-au-9\/"]}]},{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/site.uit.no\/nordco2\/2024\/05\/17\/research-article-au-9\/#primaryimage","url":"https:\/\/onlinelibrary.wiley.com\/cms\/asset\/06e1cc61-c789-4002-90dc-0d4d0e16d7e3\/anie202405344-toc-0001-m.jpg","contentUrl":"https:\/\/onlinelibrary.wiley.com\/cms\/asset\/06e1cc61-c789-4002-90dc-0d4d0e16d7e3\/anie202405344-toc-0001-m.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/site.uit.no\/nordco2\/2024\/05\/17\/research-article-au-9\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/site.uit.no\/nordco2\/"},{"@type":"ListItem","position":2,"name":"Research Article: AU"}]},{"@type":"WebSite","@id":"https:\/\/site.uit.no\/nordco2\/#website","url":"https:\/\/site.uit.no\/nordco2\/","name":"Nordic Consortium for CO2 Conversion","description":"","publisher":{"@id":"https:\/\/site.uit.no\/nordco2\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/site.uit.no\/nordco2\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Organization","@id":"https:\/\/site.uit.no\/nordco2\/#organization","name":"Nordic Consortium for CO2 Conversion","url":"https:\/\/site.uit.no\/nordco2\/","logo":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/site.uit.no\/nordco2\/#\/schema\/logo\/image\/","url":"https:\/\/site.uit.no\/nordco2\/wp-content\/uploads\/sites\/344\/2018\/01\/cropped-logonewnordco2_2-2.png","contentUrl":"https:\/\/site.uit.no\/nordco2\/wp-content\/uploads\/sites\/344\/2018\/01\/cropped-logonewnordco2_2-2.png","width":174,"height":96,"caption":"Nordic Consortium for CO2 Conversion"},"image":{"@id":"https:\/\/site.uit.no\/nordco2\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/site.uit.no\/nordco2\/#\/schema\/person\/993cf3b27a956c23c8da21d29fe6bd7c","name":"joehh","image":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/secure.gravatar.com\/avatar\/41b39828da26f7150fc97cb70bc12710fe106a864e4f01c116292a086677dd77?s=96&d=blank&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/41b39828da26f7150fc97cb70bc12710fe106a864e4f01c116292a086677dd77?s=96&d=blank&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/41b39828da26f7150fc97cb70bc12710fe106a864e4f01c116292a086677dd77?s=96&d=blank&r=g","caption":"joehh"},"url":"https:\/\/site.uit.no\/nordco2\/author\/joehh\/"}]}},"_links":{"self":[{"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/posts\/3449","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/users\/514"}],"replies":[{"embeddable":true,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/comments?post=3449"}],"version-history":[{"count":1,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/posts\/3449\/revisions"}],"predecessor-version":[{"id":3450,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/posts\/3449\/revisions\/3450"}],"wp:attachment":[{"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/media?parent=3449"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/categories?post=3449"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/site.uit.no\/nordco2\/wp-json\/wp\/v2\/tags?post=3449"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}