Publications

2022

Eric Juskewitz, Ekaterina Mishchenko, Vishesh K Dubey, Marte Jenssen, Martin Jakubec, Philip Rainsford, Johan Isaksson, Jeanette H Andersen, Johanna U Ericson, Lulworthinone: In Vitro Mode of Action Investigation of an Antibacterial Dimeric Naphthopyrone Isolated from a Marine Fungus, Marine Drugs, 2022, 20 (5), 277

2021

Marianne H Paulsen, Magnus Engqvist, Dominik Ausbacher, Trude Anderssen, Manuel K Langer, Tor Haug, Glenn R Morello, Laura E Liikanen, Hans-Matti Blencke, Johan Isaksson, Eric Juskewitz, Annette Bayer, Morten B Strøm, Amphipathic barbiturates as mimics of antimicrobial peptides and the marine natural products eusynstyelamides with activity against multi-resistant clinical isolates, Journal of Medicinal Chemistry 2021, 64 (15), 11395-11417

Marte Jenssen, Venke Kristoffersen, Kumar Motiram-Corral, Johan Isaksson, Teppo Rämä, Jeanette H Andersen, Espen H Hansen, Kine Østnes Hansen, Chlovalicin B, a Chlorinated Sesquiterpene Isolated from the Marine Mushroom Digitatispora marina, Molecules 2021, 26 (24), 7560

Marte Jenssen, Philip Rainsford, Eric Juskewitz, Jeanette H Andersen, Espen H Hansen, Johan Isaksson, Teppo Rämä, Kine Ø Hansen, Lulworthinone, a New Dimeric Naphthopyrone From a Marine Fungus in the Family Lulworthiaceae With Antibacterial Activity Against Clinical Methicillin-Resistant Staphylococcus aureus Isolates, Frontiers in microbiology, 2021, 2862

Venke Kristoffersen, Marte Jenssen, Heba Raid Jawad, Johan Isaksson, Espen H Hansen, Teppo Rämä, Kine Ø Hansen, Jeanette Hammer Andersen, Two Novel Lyso-Ornithine Lipids Isolated from an Arctic Marine Lacinutrix sp. Bacterium, Molecules 2021, 26 (17), 5295

2020

Priyanka Michael, Espen Hansen, Johan Isaksson, Jeanette H Andersen, Kine Ø Hansen, Dendrobeaniamine A, a new alkaloid from the Arctic marine bryozoan Dendrobeania murrayana, Natural Product Research 2020, 34 (14), 2059-2064

Yannik Schneider, Marte Jenssen, Johan Isaksson, Kine Østnes Hansen, Jeanette Hammer Andersen, Espen H Hansen, Bioactivity of Serratiochelin A, a Siderophore Isolated from a Co-Culture of Serratia sp. and Shewanella sp. Microorganisms 2020, 8 (7), 1042

Worku Dinku, Johan Isaksson, Fredrik Garnås Rylandsholm, Petr Bouř, Eva Brichtová, Sang Un Choi, Sang-Ho Lee, Young-Sik Jung, Zae Sung No, John Sigurd Mjøen Svendsen, Arne Jørgen Aasen, Aman Dekebo, Anti-proliferative activity of a novel tricyclic triterpenoid acid from Commiphora africana resin against four human cancer cell lines. Applied Biological Chemistry 2020, 63 (1), 1-11

Yngve Guttormsen, Magnus E Fairhurst, Sunil K Pandey, Johan Isaksson, Bengt Erik Haug, Annette Bayer, Total synthesis of phorbazole B. Molecules 2020, 25 (20), 4848

Ikenna E Ndukwe, Yu-hong Lam, Sunil K Pandey, Bengt E Haug, Annette Bayer, Edward C Sherer, Kirill A Blinov, R Thomas Williamson, Johan Isaksson, Mikhail Reibarkh, Yizhou Liu, Gary E Martin, Unequivocal structure confirmation of a breitfussin analog by anisotropic NMR measurements. Chemical science 2020, 11 (44), 12081-12088

Ida KØ Hansen, Johan Isaksson, Aaron G Poth, Kine Ø Hansen, Aaron JC Andersen, Céline SM Richard, Hans-Matti Blencke, Klara Stensvåg, David J Craik, Tor Haug, Isolation and Characterization of Antimicrobial Peptides with Unusual Disulfide Connectivity from the Colonial Ascidian Synoicum turgens. Mar. Drugs 2020, 18 (1), 51

2019

Kine Ø Hansen, Jeanette H Andersen, Annette Bayer, Sunil K Pandey, Marianne Lorentzen, Kåre B Jørgensen, Magne O Sydnes, Yngve Guttormsen, Matthias Baumann, Uwe Koch, Bert Klebl, Jan Eickhoff, Bengt Erik Haug, Johan Isaksson, Espen H Hansen, Kinase Chemodiversity from the Arctic: The Breitfussins, J. Med. Chem. 2019, 62 (22), 10167-10181

Priyanka Michael, Espen Hansen, Johan Isaksson, Jeanette H Andersen, Kine Østenes HansenDendrobeaniamine A, a new alkaloid from the Arctic marine bryozoan Dendrobeania murrayana, Nat. Prod. Res. 2019, 1-6

Yannik KH Schneider, Kine Østnes Hansen, Johan Isaksson, Sara Ullsten, Espen Hansen, Jeanette H AndersenAnti-Bacterial Effect and Cytotoxicity Assessment of Lipid 430 Isolated from Algibacter sp., Molecules 2019, 24 (21), 3991

Aitor Moreno, Kine Østnes Hansen, Johan IsakssonCSSF-CLIP-HSQMBC: measurement of heteronuclear coupling constants in severely crowded spectral regions, RSC Advances 2019, 9 (62), 36082-36087

2018

Bjarte Aarmo Lund, Ane Molden Thomassen, Birgit Helene Berg Nesheim, Trine Josefine Olsen Carlsen, Johan Isaksson, Tony Christopeit, Hanna‐Kirsti S Leiros, The biological assembly of OXA‐48 reveals a dimer interface with high charge complementarity and very high affinity, The FEBS journal 2018

Kine Østnes Hansen, Johan Isaksson, Eirin Glomsaker, Jeanette H. Andersen, Espen HansenPonasterone A and F, Ecdysteroids from the Arctic Bryozoan Alcyonidium gelatinosum, Molecules 2018, 23 (6), 1481

Jostein Grip, Rolf Einar Engstad, Ingrid Skjæveland, Nataša Škalko-Basnet, Johan Isaksson, Purusotam Basnet, Ann Mari Holsæter, Beta-glucan-loaded nanofiber dressing improves wound healing in diabetic mice, European Journal of Pharmaceutical Sciences, 2018

ChaVenke Kristoffersen, Teppo Rämä, Johan Isaksson, Jeanette Hammer Andersen, William H Gerwick, Espen Hansen, Characterization of Rhamnolipids Produced by an Arctic Marine Bacterium from the Pseudomonas fluorescence Group, Marine drugs 2018, 16 (5), 163

Sundus Akhter, Bjarte Aarmo Lund, Aya Ismael, Manuel Langer, Johan Isaksson, Tony Christopeit, Hanna-Kirsti S Leiros, Annette BayerA focused fragment library targeting the antibiotic resistance enzyme-Oxacillinase-48: Synthesis, structural evaluation and inhibitor design, European journal of medicinal chemistry 2018, 145, 634-648

2017

KØ Hansen, J Isaksson, A Bayer, JA Johansen, JH Andersen, E HansenSecuramine Derivatives from the Arctic Bryozoan Securiflustra securifrons, Journal of natural products 2017, 80 (12), 3276-3283

P Michael, KØ Hansen, J Isaksson, JH Andersen, E Hansen A novel brominated alkaloid securidine A, isolated from the marine bryozoan Securiflustra securifrons, Molecules 2017, 22 (7), 1236

2016

Stierhof, M.; Hansen, K. Ø.; Sharma, M.; Feussner, K.; Subko, K.; Díaz-Rullo, F. F.; Isaksson, J.; Pérez-Victoria, I.; Clarke, D.; Hansen, E.; Jaspars, M.; Tabudravu, J. N., New cytotoxic callipeltins from the Solomon Island marine sponge Asteropus sp. Tetrahedron 2016, 72, 6929-6934.

Rothweiler, U.; Stensen, W.; Brandsdal, B. O.; Isaksson, J.; Leeson, F. A.; Engh, R. A.; Svendsen, J. S. M., Probing the ATP-Binding Pocket of Protein Kinase DYRK1A with Benzothiazole Fragment Molecules. Journal of Medicinal Chemistry 2016, 59, 9814-9824.

Albert, A.; Jacobus Johannes, E.; Isaksson, J.; Sengee, M.; Hansen, T.; Vasskog, T., General Approach To Determine Disulfide Connectivity in Cysteine-​Rich Peptides by Sequential Alkylation on Solid Phase and Mass Spectrometry. Analytical Chemistry 2016, 88, 9539-9546.

Solstad, R. G.; Li, C.; Isaksson, J.; Johansen, J.; Svenson, J.; Stensvåg, K.; Haug, T., Novel Antimicrobial Peptides EeCentrocins 1, 2 and EeStrongylocin 2 from the Edible Sea Urchin Echinus esculentus Have 6-Br-Trp Post-Translational Modifications. PLOS ONE 2016, 11, e0151820.

Olsen, Elisabeth Klungerbo; Søderholm, Kine; Isaksson, Johan; Andersen, Jeanette hammer; Hansen, Espen. Metabolomic Profiling Reveals the N-Acyl-Taurine Geodiataurine in Extracts from the Marine Sponge Geodia macandrewii (Bowerbank). Journal of natural products (Print) 2016, 79, 1285-1291

Olsen, Elisabeth Klungerbo; Hansen, Espen; Moodie, Lindon W.K; Isaksson, Johan; Sepcic, Kristina; Cergolj, Marija; Svenson, Johan; Andersen, Jeanette hammer. Marine AChE inhibitors isolated from Geodia barretti: natural compounds and their synthetic analogs. Organic and biomolecular chemistry 2016, 14, 1629-1640

Capar, Jan; Zonneveld, Job; Berg, Steffen; Isaksson, Johan; Gagnon, Kevin J.; Thomas, Kolle E.; Ghosh, Abhik. Demetalation of copper undecaarylcorroles: Molecular structures of a free-base undecaarylisocorrole and a gold undecaarylcorrole. Journal of Inorganic Biochemistry 2016, 162, 146-153.

2015

Demissie, Taye Beyene; Kostenko, Nataliya; Komorovsky, Stanislav; Repisky, Michal; Isaksson, Johan; Bayer, Annette; Ruud, Kenneth. Experimental and four-component relativistic DFT studies of tungsten carbonyl complexes. Journal of Physical Organic Chemistry 2015, 28 (12), 723-73

2014

Sivertsen, Annfrid; Isaksson, Johan; Leiros, Hanna-Kirsti S.; Svenson, Johan; Svendsen, John Sigurd; Brandsdal, Bjørn Olav. Synthetic cationic antimicrobial peptides bind with their hydrophobic parts to drug site II of human serum albumin. BMC Structural Biology 2014, 14, 4

Sivertsen, Annfrid; Tørfoss, Veronika; Isaksson, Johan; Ausbacher, Dominik; Anderssen, Trude; Brandsdal, Bjørn Olav; Havelkova, Martina; Skjørholm, Anne Elisabeth; Strøm, Morten B..
Anticancer potency of small linear and cyclic tetrapeptides and pharmacokinetic investigations of peptide binding to human serum albumin. Journal of Peptide Science 2014 ;Volum 20.(4) s. 279-291

Trepos, R.; Cervin, G.; Hellio, C.; Pavia, H.; Stensen, W.; Stensvåg, K.; Svendsen, J.-S.; Haug, T.; Svenson, J., Antifouling Compounds from the Sub-Arctic Ascidian Synoicum pulmonaria: Synoxazolidinones A and C, Pulmonarins A and B, and Synthetic Analogues. Journal of Natural Products 2014, 77, 2105-2113.

2013

Xiaojun Li, Kathrin H. Hopmann,* Jana Hudecová, Johan Isaksson, Jana Novotná, Wenche Stensen, Valery Andrushchenko, Marie Urbanová, John-Sigurd Svendsen, Petr Bouř* and Kenneth Ruud, Determination of Absolute Configuration and Conformation of a Cyclic Dipeptide by NMR and Chiral Spectroscopic Methods. J. Phys. Chem. A 2013, 117, 1721-1736.

Elisabeth Klungerbo Olsen ,* Espen Hansen, Johan Isaksson and Jeanette H. Andersen, Cellular antioxidant effect of four bromophenols from the red algae Vertebrata lanosa. Mar. Drugs 2013, 11, 2769-2784.

Taye B. Demissie, Michal Repisky, Stanislav Komorovsky, Johan Isaksson, John S. Svendsen, Helena Dodziuk and Kenneth Ruud,* Four-component relativistic chemical shift calculations of halogenated organic compounds. J. Phys. Org. Chem. 2013, 26, 679-687.

2012

Kine Ø. Hanssen, Bruno Schuler, Antony J. Williams, Taye B. Demissie, Espen Hansen, Jeanette H. Andersen, Johan Svenson, Kirill Blinov, Michal Repisky, Fabian Mohn, Gerhard Meyer, John-Sigurd Svendsen, Kenneth Ruud, Mikhail Elyashberg, Leo Gross, Marcel Jaspars,* and Johan Isaksson,* A Combined Atomic Force Microscopy and Computational Approach for the Structural Elucidation of Breitfussin A and B: Highly Modified Halogenated Dipeptides from Thuiaria breitfussi. Angew. Chem. Int. Ed. 2012, 51, 12238-12241.

Veronika Tørfoss, Johan Isaksson, Dominik Ausbacher, Bjørn-Olav Brandsdal, Gøril E. Flaten, Trude Anderssen, Cristiane de A. Cavalcanti-Jacobsen, Martina Havelkova, Leonard T. Nguyen, Hans J. Vogel and Morten B. Strøm,* Improved anticancer potency by head-to-tail cyclization of short cationic anticancer peptides containing a lipophilic b2,2-amino acid. J. Pept. Sci. 2012, 18, 609-619.

Hopmann, K. H.; Šebestík, J.; Novotná, J.; Stensen, W.; Urbanová, M.; Svenson, J.; Svendsen, J. S.; Bouř, P.; Ruud, K., Determining the Absolute Configuration of Two Marine Compounds Using Vibrational Chiroptical Spectroscopy. The Journal of Organic Chemistry 2012, 77, 858-869.

2011

Johan Isaksson, Bjørn O. Brandsdal, Magnus Engqvist, Gøril Eide Flaten, John S. Mjøen Svendsen and Wenche Stensen.* A Synthetic Antimicrobial Peptidomimetic (LTX 109): Stereochemical Impact on Membrane Disruption. J. Med. Chem. 2011, 54, 5786-5795.

Tadesse, M.; Svenson, J.; Jaspars, M.; Strøm, M. B.; Abdelrahman, M. H.; Andersen, J. H.; Hansen, E.; Kristiansen, P. E.; Stensvåg, K.; Haug, T., Synoxazolidinone C; a bicyclic member of the synoxazolidinone family with antibacterial and anticancer activities. Tetrahedron Letters 2011, 52, 1804-1806.

2010

Tadesse, M.; Strøm, M. B.; Svenson, J.; Jaspars, M.; Milne, B. F.; Tørfoss, V.; Andersen, J. H.; Hansen, E.; Stensvåg, K.; Haug, T., Synoxazolidinones A and B: Novel Bioactive Alkaloids from the Ascidian Synoicum pulmonaria. Organic Letters 2010, 12, 4752-4755.