{"id":41,"date":"2017-03-21T11:30:00","date_gmt":"2017-03-21T10:30:00","guid":{"rendered":"https:\/\/site.uit.no\/smallstruct\/?page_id=41"},"modified":"2019-01-11T01:05:09","modified_gmt":"2019-01-11T00:05:09","slug":"front-page","status":"publish","type":"page","link":"https:\/\/site.uit.no\/smallstruct\/","title":{"rendered":""},"content":{"rendered":"

SmallStruct\u00a0is a technology & competence latform\u00a0employing\u00a0various spectroscopic and theoretic methods to solve structural problems, ranging from the structure elucidation\u00a0of small natural products and peptides, to the determination of absolute and relative configuration and the characterization of interactions between small molecules and macromolecules.<\/strong><\/p>\n

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Organization<\/strong><\/h2>\n

SmallStruct is an independent platform launched in conjunction with the startup of the MABCENT-SFI <\/span><\/a>in 2007. The platform has a flat organization consisting of a network of researchers at the Arctic University of Norway<\/span><\/a>, each contributing with access to the instrumentation <\/span><\/a>as well as their expertise in the analytical- or computational methods<\/span><\/a>. The platform welcomes scientific collaboration initiatives on projects that relate to the main activities of the group.<\/p>\n

Platform leader
\n<\/strong><\/h4>\n
John Sigurd Svendsen<\/span><\/a><\/h5>\n

Phone: +47-776 44086<\/p>\n

Platform manager<\/h4>\n

Johan Isaksson<\/span><\/a><\/h5>\n

Phone; +47-776\u00a0 44842
\nEmail:contact@smallstruct.no<\/span><\/a><\/p>\n

Members and function<\/strong><\/h4>\n\n\n\n\n\n\n\n\n
Bj\u00f8rn Olav Brandsdahl<\/span><\/a><\/td>\nCTCC<\/span><\/a><\/td>\n\u00a0<\/span><\/td>\nMD and\u00a0ITC studies of ligand:macromolecule interactions<\/td>\n<\/tr>\n
Kathrin H. Hopmann<\/span><\/a><\/td>\nCTCC<\/span><\/a><\/td>\n\u00a0<\/span><\/td>\nDFT calculations of spectral parameters, and simulation of spectra<\/td>\n<\/tr>\n
Johan Isaksson<\/span><\/a><\/td>\nIK<\/span><\/a><\/td>\n\u00a0<\/span><\/td>\nNMR<\/span><\/a> acquisition, interpretation and simulation<\/td>\n<\/tr>\n
Annette Bayer<\/span><\/a><\/td>\nIK<\/span><\/a><\/td>\n\u00a0<\/span><\/td>\nSynthesis, coordinating with the Norwegian Synthesis Network, Chiral separation<\/td>\n<\/tr>\n
Jostein A. Johansen<\/span><\/a><\/td>\nIK<\/span><\/a><\/td>\n\u00a0<\/span><\/td>\nMS acquisition, isotope fitting and fragmentation simulation<\/td>\n<\/tr>\n
Ronny Helland<\/span><\/a><\/td>\nNorstruct<\/span><\/a><\/td>\n\u00a0<\/span><\/td>\nCrystallization, acquisition\u00a0and data processing of x-ray data<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Local partners<\/strong><\/h4>\n\n\n\n\n\n\n\n\n
Michal Repisky<\/span><\/a><\/td>\nCTCC<\/span><\/a><\/td>\n\u00a0<\/span><\/td>\nRelativistic calculations of spectral parameters near heavy- or paramagnetic elements<\/td>\n<\/tr>\n
J\u00f8rn H. Hansen<\/span><\/a><\/td>\nIK<\/span><\/a><\/td>\n\u00a0<\/span><\/td>\nSynthesis<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Workflow<\/strong><\/h4>\n

\"\"<\/p>\n

SmallStruct is designed to be capable of working as a self-sufficient module that easily can\u00a0be integrated in various project\u00a0pipelines. The figure above shows schematically\u00a0how a question that is the result of\u00a0upstream\u00a0work\u00a0can be put into the left connector, whereupon SmallStruct allocates the resources needed to solve that particular structural problem and delivers the result downstream at the right connector. As an example, if you hover the mouse cursor over the figure it illustrates the response to such a query, in this case\u00a0about the relative and absolute stereochemistry of a molecule\u00a0(when crystallization is not\u00a0feasible), activating the Nuclear Magnetic Resonance- (NMR), Ab initio<\/em> calculation-\u00a0(DFT) and Optical Rotation (VCD, ROA, ORD)\u00a0branches required to answer the question.<\/p>\n

History<\/strong><\/h4>\n

MabCent-SFI was launched 2007 as a centre for research based innovation with a focus on marine bioprospecting. It is based in Troms\u00f8 which allows relatively near access to arctic, sub-arctic and marine organisms. Arctic marine organisms are forced\u00a0to\u00a0adapt to life in an extreme environment\u00a0in order to survive. The induced molecular adaption has lead to unusual chemistry that produces novel bioactive molecules of interest.<\/p>\n","protected":false},"excerpt":{"rendered":"

SmallStruct\u00a0is a technology & competence latform\u00a0employing\u00a0various spectroscopic and theoretic methods to solve structural problems, ranging from the structure elucidation\u00a0of small natural products and peptides, to the determination of absolute and relative configuration and the characterization of interactions between small molecules … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":709,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-41","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/site.uit.no\/smallstruct\/wp-json\/wp\/v2\/pages\/41","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/site.uit.no\/smallstruct\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/site.uit.no\/smallstruct\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/site.uit.no\/smallstruct\/wp-json\/wp\/v2\/users\/709"}],"replies":[{"embeddable":true,"href":"https:\/\/site.uit.no\/smallstruct\/wp-json\/wp\/v2\/comments?post=41"}],"version-history":[{"count":7,"href":"https:\/\/site.uit.no\/smallstruct\/wp-json\/wp\/v2\/pages\/41\/revisions"}],"predecessor-version":[{"id":149,"href":"https:\/\/site.uit.no\/smallstruct\/wp-json\/wp\/v2\/pages\/41\/revisions\/149"}],"wp:attachment":[{"href":"https:\/\/site.uit.no\/smallstruct\/wp-json\/wp\/v2\/media?parent=41"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}